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| | <StructureSection load='5fka' size='340' side='right'caption='[[5fka]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='5fka' size='340' side='right'caption='[[5fka]], [[Resolution|resolution]] 2.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5fka]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FKA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5fka]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FKA FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fk9|5fk9]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [https://pdbe.org/5fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [https://www.ebi.ac.uk/pdbsum/5fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fka ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [http://pdbe.org/5fka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [http://www.ebi.ac.uk/pdbsum/5fka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fka ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/ETXE_STAAU ETXE_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. | + | [https://www.uniprot.org/uniprot/ETXE_STAAU ETXE_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lindkvist-Petersson, K]] | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: Regenthal, P]] | + | [[Category: Lindkvist-Petersson K]] |
| - | [[Category: Rodstrom, K E.J]]
| + | [[Category: Regenthal P]] |
| - | [[Category: Immune system]] | + | [[Category: Rodstrom KEJ]] |
| - | [[Category: Major histocompatibility complex]] | + | |
| - | [[Category: Staphylcococcal enterotoxin]]
| + | |
| - | [[Category: Superantigen]]
| + | |
| - | [[Category: T cell receptor]]
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| Structural highlights
Function
ETXE_STAAU Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Publication Abstract from PubMed
Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a massive T cell activation and hence disease. Due to high stability and toxicity, superantigens are potential agents of bioterrorism. Hence, antagonists may not only be useful in the treatment of disease but also serve as countermeasures to biological warfare. Of particular interest are inhibitors against SEA and SEB. SEA is the main cause of food poisoning, while SEB is a common toxin manufactured as a biological weapon. Here, we present the crystal structures of SEA in complex with TCR and SEE in complex with the same TCR, complemented with computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and SEH. We have identified two common areas that contribute to the general TCR binding for these superantigens. This paves the way for design of single antagonists directed towards multiple toxins.
Two common structural motifs for TCR recognition by staphylococcal enterotoxins.,Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K. Two common structural motifs for TCR recognition by staphylococcal enterotoxins. Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909 doi:http://dx.doi.org/10.1038/srep25796
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