1lf8
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(New page: 200px<br /> <applet load="1lf8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lf8, resolution 2.30Å" /> '''Complex of GGA3-VHS...)
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Revision as of 15:53, 12 November 2007
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Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
Contents |
Overview
Phosphorylation of the cytosolic tails of transmembrane receptors can, regulate their intracellular trafficking. The structural basis for such, regulation, however, has not been explained in most cases. The cytosolic, tail of the cation-independent mannose 6-phosphate receptor contains a, serine residue within an acidic-cluster dileucine signal that is important, for the function of the receptor in the biosynthetic sorting of lysosomal, hydrolases. We show here that phosphorylation of this Ser enhances, interactions of the signal with its recognition module, the VHS domain of, the GGA proteins. Crystallographic analyses demonstrate that the, phosphoserine residue interacts electrostatically with two basic residues, on the VHS domain of GGA3, thus providing an additional point of, attachment of the acidic-cluster dileucine signal to its recognition, module.
Disease
Known diseases associated with this structure: Hepatocellular carcinoma OMIM:[147280]
About this Structure
1LF8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism., Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS, Nat Struct Biol. 2002 Jul;9(7):532-6. PMID:12032548
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