5fn7

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Current revision (06:59, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fn7' size='340' side='right'caption='[[5fn7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5fn7' size='340' side='right'caption='[[5fn7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fn7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fn7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FN7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fmv|5fmv]], [[5fn6|5fn6]], [[5fn8|5fn8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn7 OCA], [https://pdbe.org/5fn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fn7 RCSB], [https://www.ebi.ac.uk/pdbsum/5fn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn7 OCA], [http://pdbe.org/5fn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn7 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn7 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN]] T-B+ severe combined immunodeficiency due to CD45 deficiency. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN] T-B+ severe combined immunodeficiency due to CD45 deficiency. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN]] Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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[https://www.uniprot.org/uniprot/PTPRC_HUMAN PTPRC_HUMAN] Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Aricescu AR]]
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[[Category: Aricescu, A R]]
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[[Category: Chang VT]]
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[[Category: Chang, V T]]
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[[Category: Coles CH]]
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[[Category: Coles, C H]]
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[[Category: Davis SJ]]
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[[Category: Davis, S J]]
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[[Category: Fernandes RA]]
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[[Category: Fernandes, R A]]
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[[Category: Ganzinger KA]]
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[[Category: Ganzinger, K A]]
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[[Category: Gilbert RJC]]
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[[Category: Gilbert, R J.C]]
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[[Category: Harlos K]]
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[[Category: Harlos, K]]
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[[Category: Huang E]]
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[[Category: Huang, E]]
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[[Category: Jones EY]]
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[[Category: Jones, E Y]]
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[[Category: Jonsson P]]
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[[Category: Jonsson, P]]
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[[Category: Klenerman D]]
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[[Category: Klenerman, D]]
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[[Category: Lee SF]]
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[[Category: Lee, S F]]
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[[Category: Lui Y]]
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[[Category: Lui, Y]]
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[[Category: McColl J]]
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[[Category: McColl, J]]
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[[Category: Palayret M]]
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[[Category: Palayret, M]]
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[[Category: Siebold C]]
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[[Category: Siebold, C]]
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[[Category: Cd45]]
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[[Category: Hydrolase]]
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[[Category: Ptprc]]
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[[Category: Receptor protein tyrosine phosphatase c]]
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Current revision

Crystal structure of human CD45 extracellular region, domains d1-d2

PDB ID 5fn7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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