Nitroreductase

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Line 18: Line 18:
*Nitroreductase
*Nitroreductase
-
**[[1f5v ]], [[1oo5]] – EcNR + FMN – ''Escherichia coli''<br />
+
**[[3bm1]], [[1ds7]] – EcNR minimal + FMN – ''Escherichia coli''<br />
-
**[[3x21]], [[3x22]] – EcNR (mutant) + FMN<br />
+
-
**[[3bm1]], [[1ds7]] – EcNR minimal + FMN<br />
+
**[[3bm2]] – EcNR minimal -FMN<br />
**[[3bm2]] – EcNR minimal -FMN<br />
**[[1nec]], [[1kqd]] – EclNR + FMN – ''Enterobacter cloacae''<br />
**[[1nec]], [[1kqd]] – EclNR + FMN – ''Enterobacter cloacae''<br />
 +
**[[1kqb]], [[5j8g]]– EclNR + FMN + benzoate derivative<br />
 +
**[[1kqc]] – EclNR + FMN + acetate<br />
**[[1ywq]], [[2i7h]] – NR + FMN – ''Bacillus cereus''<br />
**[[1ywq]], [[2i7h]] – NR + FMN – ''Bacillus cereus''<br />
**[[5hdj]] – NR + FMN – ''Bacillus megaterium''<br />
**[[5hdj]] – NR + FMN – ''Bacillus megaterium''<br />
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**[[3k6h]] – NR + FMN – ''Agrobacterium tumefaciens''<br />
**[[3k6h]] – NR + FMN – ''Agrobacterium tumefaciens''<br />
**[[2wzv]], [[2ymv]] – MsNR + FMN – ''Mycobacterium smegmatis''<br />
**[[2wzv]], [[2ymv]] – MsNR + FMN – ''Mycobacterium smegmatis''<br />
 +
**[[2wzw]] - MsNR + FMN + NADPH<br />
**[[3of4]] – NR + FMN + FAD – ''Idiomarina loihiensis''<br />
**[[3of4]] – NR + FMN + FAD – ''Idiomarina loihiensis''<br />
**[[3n2s]] – NR + FMN – ''Bacillus subtilis''<br />
**[[3n2s]] – NR + FMN – ''Bacillus subtilis''<br />
**[[3pxv]] – NR + FMN – ''Desulfitobacterium hafniense''<br />
**[[3pxv]] – NR + FMN – ''Desulfitobacterium hafniense''<br />
-
**[[3qdl]] – NR + FMN – ''Helicobacter pylori''<br />
 
**[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br />
**[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br />
**[[3ge6]] – NR + FMN – ''Exiguobacterium sibiricum''<br />
**[[3ge6]] – NR + FMN – ''Exiguobacterium sibiricum''<br />
Line 43: Line 43:
**[[7dp0]] – SpNR + FMN – ''Sphingopyxis''<br />
**[[7dp0]] – SpNR + FMN – ''Sphingopyxis''<br />
**[[7dp1]], [[7dp2]] – SpNR (mutant) + FMN <br />
**[[7dp1]], [[7dp2]] – SpNR (mutant) + FMN <br />
-
**[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br />
 
*Copper-induced nitroreductase
*Copper-induced nitroreductase
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**[[4z85]] – NR – ''Psudomonas fluorescens''<br />
**[[4z85]] – NR – ''Psudomonas fluorescens''<br />
 +
 +
*Oxygen-insensitive NADPH nitroreductase
-
*Nitroreductase complex
+
**[[1f5v]], [[1oo5]], [[7q0o]] – EcNR + FMN <br />
-
 
+
**[[3x21]], [[3x22]] – EcNR (mutant) + FMN<br />
-
**[[1kqb]], [[5j8g]]– EclNR + FMN + benzoate derivative<br />
+
**[[7z0w]] – EcNR + FMN + adenosine derivative<br />
-
**[[1kqc]] – EclNR + FMN + acetate<br />
+
**[[7xww]] – EcNR + FMN + pyridine derivative<br />
 +
**[[8c5e]], [[8ccv]], [[8cj0]] – EcNR (mutant) + FMN + nicotinic acid<br />
**[[1ylr]], [[1ylu]] - EcNR + FMN + acetate<br />
**[[1ylr]], [[1ylu]] - EcNR + FMN + acetate<br />
 +
**[[8c5f]], [[8c5p]] – EcNR (mutant) + FMN + acetate<br />
 +
**[[8og3]] – EcNR (mutant) + FMN + citrate<br />
 +
**[[7niy]] – EcNR (mutant) + FMN + imidazole<br />
 +
**[[8ajx]] – EcNR + FMN + fumarate<br />
 +
**[[7x32]] – EcNR + FMN + berberine<br />
 +
**[[7nb9]] – EcNR + FMN + nitrofurantoin<br />
 +
**[[7nmp]], [[7nnx]] – EcNR + FMN + quinone derivative<br />
**[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + FMN + NAD derivative<br />
**[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + FMN + NAD derivative<br />
**[[1ooq]] – EcNR + FMN + dicoumarol<br />
**[[1ooq]] – EcNR + FMN + dicoumarol<br />
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + FMN + benzamide derivative<br />
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + FMN + benzamide derivative<br />
**[[1yki]] – EcNR + FMN + antibiotic<br />
**[[1yki]] – EcNR + FMN + antibiotic<br />
-
**[[7nb9]] – EcNR + FMN + nitrofurantoin<br />
+
**[[6czp]] – VvNR + FMN – Vibrio vulnificus<br />
-
**[[7nmp]], [[7nnx]] – EcNR + FMN + quinone derivative<br />
+
**[[7uwt]] – VvNR (mutant) + FMN<br />
-
**[[7niy]] – EcNR (mutant) + FMN + imidazole<br />
+
**[[3qdl]] – NR + FMN – Helicobacter pylori<br />
-
**[[2wzw]] - MsNR + FMN + NADPH<br />
+
 
-
**[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br />
+
*Deazaflavin-dependent nitroreductase
-
**[[3r5r]], [[3r5w]] – MtNR F420<br />
+
 
 +
**[[3r5r]], [[3r5w]], [[7kl8]] – MtNR + coenzyme F420<br />
 +
 
 +
*NADPH nitroreductase
 +
 
 +
**[[7tmf]], [[7tmg]] – NR + FMN – Klebsiella pneumoniae<br />
 +
 
 +
*NADPH-flavin nitroreductase
 +
 
 +
**[[5uu6]] – NR + FMN – Vibrio parahaemolyticus<br />
 +
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:48, 19 July 2023

E. coli nitroreductase dimer containing FMN and nicotinic acid (PDB entry 1icr)

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3D structures of nitroreductase

Updated on 19-July-2023

References

  1. ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
  2. ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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