1lmz

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[[Image:1lmz.gif|left|200px]]
[[Image:1lmz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lmz |SIZE=350|CAPTION= <scene name='initialview01'>1lmz</scene>
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The line below this paragraph, containing "STRUCTURE_1lmz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-3-methyladenine_glycosylase_I DNA-3-methyladenine glycosylase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.20 3.2.2.20] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1lmz| PDB=1lmz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmz OCA], [http://www.ebi.ac.uk/pdbsum/1lmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lmz RCSB]</span>
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}}
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'''Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)'''
'''Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)'''
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[[Category: Stivers, J T.]]
[[Category: Stivers, J T.]]
[[Category: 3-methyladenine]]
[[Category: 3-methyladenine]]
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[[Category: dna glycosylase]]
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[[Category: Dna glycosylase]]
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[[Category: enzyme]]
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[[Category: Enzyme]]
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[[Category: helix-hairpin-helix superfamily]]
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[[Category: Helix-hairpin-helix superfamily]]
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[[Category: nmr spectroscopy]]
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[[Category: Nmr spectroscopy]]
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[[Category: solution structure]]
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[[Category: Solution structure]]
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[[Category: tag]]
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[[Category: Tag]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:04:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:04:44 2008''
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Revision as of 21:04, 2 May 2008

Image:1lmz.gif

Template:STRUCTURE 1lmz

Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)


Overview

The Escherichia coli enzyme 3-methyladenine DNA glycosylase I (TAG) hydrolyzes the glycosidic bond of 3-methyladenine (3-MeA) in DNA and is found in many bacteria and some higher eukaryotes. TAG shows little primary sequence identity with members of the well-known helix-hairpin-helix (HhH) superfamily of DNA repair glycosylases, which consists of AlkA, EndoIII, MutY and hOGG1. Unexpectedly, the three-dimensional solution structure reported here reveals TAG as member of this superfamily. The restricted specificity of TAG for 3-MeA bases probably arises from its unique aromatic rich 3-MeA binding pocket and the absence of a catalytic aspartate that is present in all other HhH family members.

About this Structure

1LMZ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member., Drohat AC, Kwon K, Krosky DJ, Stivers JT, Nat Struct Biol. 2002 Sep;9(9):659-64. PMID:12161745 Page seeded by OCA on Sat May 3 00:04:42 2008

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