1log

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[[Image:1log.jpg|left|200px]]
[[Image:1log.jpg|left|200px]]
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{{Structure
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|PDB= 1log |SIZE=350|CAPTION= <scene name='initialview01'>1log</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1log", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1log| PDB=1log | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1log OCA], [http://www.ebi.ac.uk/pdbsum/1log PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1log RCSB]</span>
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}}
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'''X-RAY STRUCTURE OF A (ALPHA-MAN(1-3)BETA-MAN(1-4)GLCNAC)-LECTIN COMPLEX AT 2.1 ANGSTROMS RESOLUTION'''
'''X-RAY STRUCTURE OF A (ALPHA-MAN(1-3)BETA-MAN(1-4)GLCNAC)-LECTIN COMPLEX AT 2.1 ANGSTROMS RESOLUTION'''
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[[Category: Bourne, Y.]]
[[Category: Bourne, Y.]]
[[Category: Cambillau, C.]]
[[Category: Cambillau, C.]]
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[[Category: lectin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:07:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:05:22 2008''
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Revision as of 21:07, 2 May 2008

Image:1log.jpg

Template:STRUCTURE 1log

X-RAY STRUCTURE OF A (ALPHA-MAN(1-3)BETA-MAN(1-4)GLCNAC)-LECTIN COMPLEX AT 2.1 ANGSTROMS RESOLUTION


Overview

We describe herein the high resolution refined x-ray structure of a trisaccharide, which is a part of the N-acetyllactosamine type glycan found in the majority of the N-glycosyl-proteins, complexed to the isolectin I. According to the potentials used by Imberty et al. (Imburty, A., Gerber, S., Tran, V., and Perez, S. (1990) Glycoconjugate J. 7, 27-54) the trisaccharide is in a low-energy state. Only one mannose moiety establishes direct hydrogen bonds with the lectin, as it is the case for monosaccharide-lectin complexes. The comparison of our trisaccharide with the one determined in solution by Warin et al. (Warin, V., Baert, F., Fouret, R., Strecker, G., Fournet, B., and Montreuil, J. (1979) Carbohydr. Res. 76, 11-22) shows that both adopt roughly the same conformation. The differences in these two sugar structures allow us to assign the role of water molecules present in the vicinity of our trisaccharide for the stabilization of this sugar-lectin complex.

About this Structure

1LOG is a Protein complex structure of sequences from Lathyrus ochrus. Full crystallographic information is available from OCA.

Reference

X-ray structure of a (alpha-Man(1-3)beta-Man(1-4)GlcNAc)-lectin complex at 2.1-A resolution. The role of water in sugar-lectin interaction., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1990 Oct 25;265(30):18161-5. PMID:2211692 Page seeded by OCA on Sat May 3 00:07:03 2008

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