2hu4

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<StructureSection load='2hu4' size='340' side='right'caption='[[2hu4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2hu4' size='340' side='right'caption='[[2hu4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hu4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. The May 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Influenza Neuraminidase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_5 10.2210/rcsb_pdb/mom_2009_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HU4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hu4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. The May 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Influenza Neuraminidase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_5 10.2210/rcsb_pdb/mom_2009_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HU4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ht5|2ht5]], [[2ht7|2ht7]], [[2ht8|2ht8]], [[2htu|2htu]], [[2htq|2htq]], [[2htv|2htv]], [[2htw|2htw]], [[2hty|2hty]], [[2htr|2htr]], [[2hu0|2hu0]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu4 OCA], [https://pdbe.org/2hu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu4 OCA], [https://pdbe.org/2hu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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[https://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Influenza A virus]]
[[Category: Influenza Neuraminidase]]
[[Category: Influenza Neuraminidase]]
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[[Category: Influenza a virus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Blackburn, G M]]
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[[Category: Blackburn GM]]
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[[Category: Collins, P J]]
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[[Category: Collins PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Gamblin SJ]]
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[[Category: Haire, L F]]
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[[Category: Haire LF]]
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[[Category: Hay, A J]]
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[[Category: Hay AJ]]
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[[Category: Lin, Y P]]
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[[Category: Lin YP]]
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[[Category: Russell, R J]]
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[[Category: Russell RJ]]
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[[Category: Skehel, J J]]
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[[Category: Skehel JJ]]
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[[Category: Stevens, D J]]
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[[Category: Stevens DJ]]
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[[Category: Hydrolase]]
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[[Category: N1]]
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[[Category: Neuraminidase]]
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[[Category: Oseltamivir]]
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Revision as of 13:06, 26 July 2023

N1 neuraminidase in complex with oseltamivir 2

PDB ID 2hu4

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