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2jpx
From Proteopedia
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==A18H Vpu TM structure in lipid bilayers== | ==A18H Vpu TM structure in lipid bilayers== | ||
| - | <StructureSection load='2jpx' size='340' side='right'caption='[[2jpx | + | <StructureSection load='2jpx' size='340' side='right'caption='[[2jpx]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2jpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JPX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpx OCA], [https://pdbe.org/2jpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpx RCSB], [https://www.ebi.ac.uk/pdbsum/2jpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpx OCA], [https://pdbe.org/2jpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpx RCSB], [https://www.ebi.ac.uk/pdbsum/2jpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VPU_HV1B1 VPU_HV1B1] Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation. Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum. Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane. Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation. The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis. Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers. It is thus unsure that this activity plays a role in vivo.[HAMAP-Rule:MF_04082] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Opella | + | [[Category: Opella SJ]] |
| - | [[Category: Park | + | [[Category: Park S]] |
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Current revision
A18H Vpu TM structure in lipid bilayers
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