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2q8y

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Current revision (13:10, 26 July 2023) (edit) (undo)
 
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<StructureSection load='2q8y' size='340' side='right'caption='[[2q8y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2q8y' size='340' side='right'caption='[[2q8y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2q8y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2q8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Enteritidis Salmonella enterica subsp. enterica serovar Enteritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Y FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8y OCA], [https://pdbe.org/2q8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8y RCSB], [https://www.ebi.ac.uk/pdbsum/2q8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8y OCA], [https://pdbe.org/2q8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8y RCSB], [https://www.ebi.ac.uk/pdbsum/2q8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/VRP3_SALEN VRP3_SALEN]] Not known. This protein is involved in the virulence of salmonellas. [[https://www.uniprot.org/uniprot/MK07_HUMAN MK07_HUMAN]] Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.<ref>PMID:9384584</ref> <ref>PMID:9790194</ref> <ref>PMID:11254654</ref> <ref>PMID:11278431</ref> <ref>PMID:22869143</ref>
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[https://www.uniprot.org/uniprot/SPVC_SALEN SPVC_SALEN] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif present in MAPKs, via a beta-elimination reaction leading to a dehydrobutyrine residue.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mitogen-activated protein kinase]]
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[[Category: Salmonella enterica subsp. enterica serovar Enteritidis]]
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[[Category: Shao, F]]
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[[Category: Shao F]]
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[[Category: Wang, D C]]
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[[Category: Wang D-C]]
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[[Category: Zhu, Y Q]]
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[[Category: Zhu Y-Q]]
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[[Category: Alpha/beta fold]]
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[[Category: Lyase-transferase complex]]
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Current revision

Structural insight into the enzymatic mechanism of the phophothreonine lyase

PDB ID 2q8y

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