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| | <StructureSection load='5g23' size='340' side='right'caption='[[5g23]], [[Resolution|resolution]] 1.85Å' scene=''> | | <StructureSection load='5g23' size='340' side='right'caption='[[5g23]], [[Resolution|resolution]] 1.85Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5g23]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G23 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G23 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5g23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G23 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g24|5g24]], [[5g25|5g25]], [[5g2f|5g2f]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g23 OCA], [http://pdbe.org/5g23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g23 RCSB], [http://www.ebi.ac.uk/pdbsum/5g23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g23 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g23 OCA], [https://pdbe.org/5g23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g23 RCSB], [https://www.ebi.ac.uk/pdbsum/5g23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g23 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q5SIZ5_THET8 Q5SIZ5_THET8] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Thet8]] | + | [[Category: Thermus thermophilus HB8]] |
| - | [[Category: Derrick, J P]] | + | [[Category: Derrick JP]] |
| - | [[Category: Karuppiah, V]] | + | [[Category: Karuppiah V]] |
| - | [[Category: Dna uptake]]
| + | |
| - | [[Category: Natural competence]]
| + | |
| - | [[Category: Structural protein]]
| + | |
| - | [[Category: Type iv pilus]]
| + | |
| Structural highlights
Function
Q5SIZ5_THET8
Publication Abstract from PubMed
Type IV pilins are proteins which form polymers that extend from the surface of the bacterial cell; they are involved in mediating a wide variety of functions, including adhesion, motility and natural competence. Here we describe the determination of the crystal structures of three type IVa pilins proteins from the thermophile Thermus thermophilus. They form part of a cluster of pilus-like proteins within the genome; our results show that one, Tt1222, is very closely related to the main structural type IV pilin, PilA4. The other two, Tt1218 and Tt1219, also adopt canonical pilin-like folds but, interestingly, are most closely related to the structures of the type II secretion system pseudopilins, EpsI/GspI and XcpW/GspJ. GspI and GspJ have been shown to form a complex with another pseudopilin, GspK, and this heterotrimeric complex is known to play a key role in initiating assembly of a pseudopilus which is thought to drive the secretion process. The structural similarity of Tt1218 and Tt1219 to GspI and GspJ suggests that they might work in a similar way, to deliver functions associated with type IV pili in T. thermophilus, such as natural competence.
Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins.,Karuppiah V, Thistlethwaite A, Derrick JP J Struct Biol. 2016 Sep 6. pii: S1047-8477(16)30175-7. doi:, 10.1016/j.jsb.2016.08.006. PMID:27612581[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Karuppiah V, Thistlethwaite A, Derrick JP. Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins. J Struct Biol. 2016 Sep 6. pii: S1047-8477(16)30175-7. doi:, 10.1016/j.jsb.2016.08.006. PMID:27612581 doi:http://dx.doi.org/10.1016/j.jsb.2016.08.006
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