1lpv
From Proteopedia
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[[Image:1lpv.jpg|left|200px]] | [[Image:1lpv.jpg|left|200px]] | ||
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'''DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES''' | '''DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LPV is a [[Single protein]] structure | + | 1LPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Wilken, J.]] | [[Category: Wilken, J.]] | ||
[[Category: Zhu, L.]] | [[Category: Zhu, L.]] | ||
| - | [[Category: | + | [[Category: Dna binding]] |
| - | [[Category: | + | [[Category: Drosophila melanogaster]] |
| - | [[Category: | + | [[Category: Gene regulation]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: Transcription]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:09:38 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:09, 2 May 2008
DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES
Overview
Sex determination is regulated by diverse pathways. Although upstream signals vary, a cysteine-rich DNA-binding domain (the DM motif) is conserved within downstream transcription factors of Drosophila melanogaster (Doublesex) and Caenorhabditis elegans (MAB-3). Vertebrate DM genes have likewise been identified and, remarkably, are associated with human sex reversal (46, XY gonadal dysgenesis). Here we demonstrate that the structure of the Doublesex domain contains a novel zinc module and disordered tail. The module consists of intertwined CCHC and HCCC Zn(2+)-binding sites; the tail functions as a nascent recognition alpha-helix. Mutations in either Zn(2+)-binding site or tail can lead to an intersex phenotype. The motif binds in the DNA minor groove without sharp DNA bending. These molecular features, unusual among zinc fingers and zinc modules, underlie the organization of a Drosophila enhancer that integrates sex- and tissue-specific signals. The structure provides a foundation for analysis of DM mutations affecting sexual dimorphism and courtship behavior.
About this Structure
1LPV is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers., Zhu L, Wilken J, Phillips NB, Narendra U, Chan G, Stratton SM, Kent SB, Weiss MA, Genes Dev. 2000 Jul 15;14(14):1750-64. PMID:10898790 Page seeded by OCA on Sat May 3 00:09:38 2008
