8gex
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the ferric enterobactin transporter (XusB) from Bacteroides thetaiotaomicron== | |
| + | <StructureSection load='8gex' size='340' side='right'caption='[[8gex]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8gex]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GEX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gex OCA], [https://pdbe.org/8gex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gex RCSB], [https://www.ebi.ac.uk/pdbsum/8gex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gex ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0P0ENH6_BACT4 A0A0P0ENH6_BACT4] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients such as iron. Pathogens scavenge iron using siderophores, which is counteracted by the host using lipocalin-2, a protein that sequesters iron-laden siderophores, including enterobactin. Although the host and pathogens compete for iron in the presence of gut commensal bacteria, the roles of commensals in nutritional immunity involving iron remain unexplored. Here, we report that the gut commensal Bacteroides thetaiotaomicron acquires iron in the inflamed gut by utilizing siderophores produced by other bacteria including Salmonella, via a secreted siderophore-binding lipoprotein termed XusB. Notably, XusB-bound siderophores are less accessible to host sequestration by lipocalin-2 but can be "re-acquired" by Salmonella , allowing the pathogen to evade nutritional immunity. As the host and pathogen have been the focus of studies of nutritional immunity, this work adds commensal iron metabolism as a previously unrecognized mechanism modulating the interactions between pathogen and host nutritional immunity. | ||
| - | + | Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection.,Spiga L, Fansler RT, Perera YR, Shealy NG, Munneke MJ, Torres TP, David HE, Lemoff A, Ran X, Richardson KL, Pudlo N, Martens EC, Yang ZJ, Skaar EP, Byndloss MX, Chazin WJ, Zhu W bioRxiv. 2023 Jun 26:2023.06.25.546471. doi: 10.1101/2023.06.25.546471. Preprint. PMID:37425782<ref>PMID:37425782</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Chazin | + | <div class="pdbe-citations 8gex" style="background-color:#fffaf0;"></div> |
| - | [[Category: Perera | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacteroides thetaiotaomicron]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chazin WJ]] | ||
| + | [[Category: Perera YR]] | ||
Revision as of 10:38, 2 August 2023
Crystal structure of the ferric enterobactin transporter (XusB) from Bacteroides thetaiotaomicron
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