8jr9

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m (Protected "8jr9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8jr9 is ON HOLD
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==Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)==
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<StructureSection load='8jr9' size='340' side='right'caption='[[8jr9]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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Authors: Zhao, L., He, Q., Yuan, Q., Gu, Y., He, X., Shan, H., Li, J., Wang, K., Li, Y., Hu, W., Wu, K., Shen, J., Xu, H.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jr9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JR9 FirstGlance]. <br>
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Description: Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KHF:1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione'>KHF</scene></td></tr>
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[[Category: Xu, H.E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jr9 OCA], [https://pdbe.org/8jr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jr9 RCSB], [https://www.ebi.ac.uk/pdbsum/8jr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jr9 ProSAT]</span></td></tr>
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[[Category: Zhao, L]]
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</table>
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[[Category: He, X]]
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== Function ==
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[[Category: Wu, K]]
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[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
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[[Category: Shan, H]]
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== References ==
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[[Category: He, Q]]
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<references/>
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[[Category: Li, J]]
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__TOC__
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[[Category: Yuan, Q]]
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</StructureSection>
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[[Category: Li, Y]]
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[[Category: Homo sapiens]]
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[[Category: Wang, K]]
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[[Category: Large Structures]]
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[[Category: Shen, J]]
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[[Category: Mus musculus]]
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[[Category: Gu, Y]]
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[[Category: Gu Y]]
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[[Category: Hu, W]]
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[[Category: He Q]]
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[[Category: He X]]
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[[Category: Hu W]]
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[[Category: Li J]]
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[[Category: Li Y]]
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[[Category: Shan H]]
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[[Category: Shen J]]
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[[Category: Wang K]]
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[[Category: Wu K]]
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[[Category: Xu HE]]
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[[Category: Yuan Q]]
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[[Category: Zhao L]]

Revision as of 10:39, 2 August 2023

Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)

PDB ID 8jr9

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