8swj

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Current revision (10:41, 2 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8swj is ON HOLD
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==Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531==
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<StructureSection load='8swj' size='340' side='right'caption='[[8swj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Zeng, H., Dong, A., Shell, D.J., Foley, C., Pearce, K.H., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8swj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SWJ FirstGlance]. <br>
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Description: Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=WWQ:(3S)-N-(4-carbamoyl[1,1-biphenyl]-3-yl)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]piperidine-3-carboxamide'>WWQ</scene></td></tr>
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[[Category: Edwards, A.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8swj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8swj OCA], [https://pdbe.org/8swj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8swj RCSB], [https://www.ebi.ac.uk/pdbsum/8swj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8swj ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Dong, A]]
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== Disease ==
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[[Category: Structural Genomics Consortium (Sgc)]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[[Category: Foley, C]]
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== Function ==
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[[Category: Halabelian, L]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[[Category: Zeng, H]]
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== References ==
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[[Category: Pearce, K.H]]
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<references/>
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[[Category: Shell, D.J]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Foley C]]
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[[Category: Halabelian L]]
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[[Category: Pearce KH]]
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[[Category: Shell DJ]]
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[[Category: Zeng H]]

Current revision

Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC8531

PDB ID 8swj

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