1bb5
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='1bb5' size='340' side='right'caption='[[1bb5]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1bb5' size='340' side='right'caption='[[1bb5]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BB5 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bb5 OCA], [https://pdbe.org/1bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bb5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bb5 OCA], [https://pdbe.org/1bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bb5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 29: | Line 29: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Headley AG]] | |
| - | [[Category: Headley | + | [[Category: Pearl LH]] |
| - | [[Category: Pearl | + | [[Category: Roe SM]] |
| - | [[Category: Roe | + | |
| - | + | ||
| - | + | ||
Current revision
HUMAN LYSOZYME MUTANT A96L COMPLEXED WITH CHITOTRIOSE
| |||||||||||
