5ggz

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<StructureSection load='5ggz' size='340' side='right'caption='[[5ggz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='5ggz' size='340' side='right'caption='[[5ggz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ggz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GGZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GGZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ggz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GGZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TN:[2,4-BIS(OXIDANYL)-5-PROPAN-2-YL-PHENYL]-(2-ETHOXY-7,8-DIHYDRO-5~{H}-PYRIDO[4,3-D]PYRIMIDIN-6-YL)METHANONE'>6TN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.015&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TN:[2,4-BIS(OXIDANYL)-5-PROPAN-2-YL-PHENYL]-(2-ETHOXY-7,8-DIHYDRO-5~{H}-PYRIDO[4,3-D]PYRIMIDIN-6-YL)METHANONE'>6TN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ggz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ggz OCA], [http://pdbe.org/5ggz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ggz RCSB], [http://www.ebi.ac.uk/pdbsum/5ggz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ggz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ggz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ggz OCA], [https://pdbe.org/5ggz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ggz RCSB], [https://www.ebi.ac.uk/pdbsum/5ggz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ggz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, T T]]
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[[Category: Chen TT]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Xu, Y C]]
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[[Category: Xu YC]]
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[[Category: Chaperone-chaperone inhibitor complex]]
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[[Category: Hsp90]]
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Revision as of 11:31, 2 August 2023

Crystal structure of novel inhibitor bound with Hsp90

PDB ID 5ggz

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