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1lsl

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[[Image:1lsl.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1lsl", creates the "Structure Box" on the page.
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|SITE=
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|GENE= THBS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1lsl| PDB=1lsl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lsl OCA], [http://www.ebi.ac.uk/pdbsum/1lsl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lsl RCSB]</span>
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'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''
'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''
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[[Category: Wang, J H.]]
[[Category: Wang, J H.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
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[[Category: tsp-1]]
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[[Category: Tsp-1]]
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[[Category: tsr]]
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[[Category: Tsr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:14:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:06:48 2008''
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Revision as of 21:14, 2 May 2008

Image:1lsl.jpg

Template:STRUCTURE 1lsl

Crystal Structure of the Thrombospondin-1 Type 1 Repeats


Overview

Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine residues from respective strands, capped by disulfide bonds on each end. The front face of the TSR contains a right-handed spiral, positively charged groove that might be the "recognition" face, mediating interactions with various ligands. This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily.

About this Structure

1LSL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:12391027 Page seeded by OCA on Sat May 3 00:14:44 2008

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