5gtm

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Current revision (11:42, 2 August 2023) (edit) (undo)
 
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<StructureSection load='5gtm' size='340' side='right'caption='[[5gtm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5gtm' size='340' side='right'caption='[[5gtm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gtm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GTM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GTM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gtm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GTM FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gtm OCA], [http://pdbe.org/5gtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gtm RCSB], [http://www.ebi.ac.uk/pdbsum/5gtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gtm ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.896&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gtm OCA], [https://pdbe.org/5gtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gtm RCSB], [https://www.ebi.ac.uk/pdbsum/5gtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gtm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
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[https://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, Y]]
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[[Category: Chen Y]]
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[[Category: Gao, S]]
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[[Category: Gao S]]
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[[Category: Antiviral activity]]
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[[Category: Antiviral protein]]
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[[Category: Hydrolysis]]
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Current revision

Modified human MxA, nucleotide-free form

PDB ID 5gtm

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