1ltq

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[[Image:1ltq.gif|left|200px]]
[[Image:1ltq.gif|left|200px]]
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{{Structure
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|PDB= 1ltq |SIZE=350|CAPTION= <scene name='initialview01'>1ltq</scene>, resolution 2.33&Aring;
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The line below this paragraph, containing "STRUCTURE_1ltq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_5'-hydroxy-kinase Polynucleotide 5'-hydroxy-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.78 2.7.1.78] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ltq| PDB=1ltq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltq OCA], [http://www.ebi.ac.uk/pdbsum/1ltq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ltq RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE'''
'''CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE'''
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[[Category: Stoddard, B L.]]
[[Category: Stoddard, B L.]]
[[Category: Wilson, G.]]
[[Category: Wilson, G.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: p-loop]]
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[[Category: P-loop]]
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[[Category: phosphatase]]
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[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:16:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:13 2008''
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Revision as of 21:16, 2 May 2008

Image:1ltq.gif

Template:STRUCTURE 1ltq

CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE


Overview

T4 phage polynucleotide kinase (PNK) was identified over 35 years ago and has become a staple reagent for molecular biologists. The enzyme displays 5'-hydroxyl kinase, 3'-phosphatase, and 2',3'-cyclic phosphodiesterase activities against a wide range of substrates. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase. DNA repair enzymes that share conserved motifs with PNK have been identified in eukaryotes. PNK contains two functionally distinct structural domains and forms a homotetramer. The C-terminal phosphatase domain is homologous to the L-2-haloacid dehalogenase family and the N-terminal kinase domain is homologous to adenylate kinase. The active sites have been characterized through structural homology analyses and visualization of bound substrate.

About this Structure

1LTQ is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase., Galburt EA, Pelletier J, Wilson G, Stoddard BL, Structure. 2002 Sep;10(9):1249-60. PMID:12220496 Page seeded by OCA on Sat May 3 00:16:42 2008

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