1ltx
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ltx.gif|left|200px]] | [[Image:1ltx.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ltx", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | | | + | {{STRUCTURE_1ltx| PDB=1ltx | SCENE= }} |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid''' | '''Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid''' | ||
| Line 34: | Line 31: | ||
[[Category: Thoma, N H.]] | [[Category: Thoma, N H.]] | ||
[[Category: Waldmann, H.]] | [[Category: Waldmann, H.]] | ||
| - | [[Category: | + | [[Category: Lucine-rich repeat]] |
| - | [[Category: | + | [[Category: Post-translational modification]] |
| - | [[Category: | + | [[Category: Prenyltransferase]] |
| - | [[Category: | + | [[Category: Rab prenylation]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:17:05 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:17, 2 May 2008
Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid
Overview
Posttranslational geranylgeranylation of Rab GTPases is catalyzed by Rab geranylgeranyltransferase (RabGGTase), which consists of a catalytic alpha/beta heterodimer and an accessory Rab escort protein (REP). The crystal structure of isoprenoid-bound RabGGTase complexed to REP-1 has been solved to 2.7 A resolution. The complex interface buries a surprisingly small surface area of ca. 680 A and is unexpectedly formed by helices 8, 10, and 12 of the RabGGTase alpha subunit and helices D and E of REP-1. We demonstrate that the affinity of RabGGTase for REP-1 is allosterically regulated by phosphoisoprenoid via a long-range trans-domain signal transduction event. Comparing the structure of REP-1 with the closely related RabGDI, we conclude that the specificity of the REP:RabGGTase interaction is defined by differently positioned phenylalanine residues conserved in the REP and GDI subfamilies.
About this Structure
1LTX is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase., Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thoma NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K, Mol Cell. 2003 Feb;11(2):483-94. PMID:12620235 Page seeded by OCA on Sat May 3 00:17:05 2008
