7zl8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==NME1 in complex with succinyl-CoA== | |
| - | + | <StructureSection load='7zl8' size='340' side='right'caption='[[7zl8]], [[Resolution|resolution]] 1.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zl8]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCA:SUCCINYL-COENZYME+A'>SCA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl8 OCA], [https://pdbe.org/7zl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NDKA_MOUSE NDKA_MOUSE] This protein is found in reduced amount in tumor cells of high metastatic potential. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NDKA_MOUSE NDKA_MOUSE] Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Garcia-Saez I]] | ||
| + | [[Category: Iuso D]] | ||
| + | [[Category: Khochbin S]] | ||
| + | [[Category: Petosa C]] | ||
Revision as of 05:22, 9 August 2023
NME1 in complex with succinyl-CoA
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