8eo2

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m (Protected "8eo2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8eo2 is ON HOLD until Paper Publication
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==Lufaxin a bifunctional inhibitor of complement and coagulation==
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<StructureSection load='8eo2' size='340' side='right'caption='[[8eo2]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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Authors: Andersen, J.F., Strayer, E.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8eo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lutzomyia_longipalpis Lutzomyia longipalpis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EO2 FirstGlance]. <br>
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Description: Lufaxin a bifunctional inhibitor of complement and coagulation
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Andersen, J.F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eo2 OCA], [https://pdbe.org/8eo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eo2 RCSB], [https://www.ebi.ac.uk/pdbsum/8eo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eo2 ProSAT]</span></td></tr>
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[[Category: Strayer, E.C]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LUFX_LUTLO LUFX_LUTLO] Sand fly salivary protein with antithrombotic, and anti-complement (alternative pathway) activities (PubMed:22796577, PubMed:28912782). Is a slow, tight, non-competitive, and reversible inhibitor of factor Xa (FXa, F10) (PubMed:22796577). Is specific for FXa (Kd=3.86 nM) and does not interact with non-activated FX, or all other enzymes tested (PubMed:22796577). In addition, it blocks prothrombinase and increases both prothrombin time and activated partial thromboplastin time (PubMed:22796577). It also prevents protease-activated receptor 2 (F2RL1, PAR2) activation by FXa (PubMed:22796577). In vivo, it abrogates edema formation triggered by injection of FXa in the paw of mice (PubMed:22796577). Moreover, it prevents FeCl3-induced carotid artery thrombus formation and prolongs activated partial thromboplastin time ex vivo, implying that it works as an anticoagulant in vivo (PubMed:22796577). It also inhibits the early steps of the alternative pathway of complement by direct binding to the proconvertase C3b-B complex, by inhibiting activation of factor B and consequently the formation of the C3 convertase (PubMed:28912782).<ref>PMID:22796577</ref> <ref>PMID:28912782</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lutzomyia longipalpis]]
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[[Category: Andersen JF]]
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[[Category: Strayer EC]]

Revision as of 05:26, 9 August 2023

Lufaxin a bifunctional inhibitor of complement and coagulation

PDB ID 8eo2

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