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8huo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of human PPAR delta ligand binding domain-seladelpar co-crystals obtained by co-crystallization== | |
| - | + | <StructureSection load='8huo' size='340' side='right'caption='[[8huo]], [[Resolution|resolution]] 2.67Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8huo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.671Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KKB:Seladelpar'>KKB</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8huo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8huo OCA], [https://pdbe.org/8huo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8huo RCSB], [https://www.ebi.ac.uk/pdbsum/8huo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8huo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Honda A]] | ||
| + | [[Category: Ishii I]] | ||
| + | [[Category: Kamata S]] | ||
| + | [[Category: Machida Y]] | ||
| + | [[Category: Masuda R]] | ||
| + | [[Category: Oyama T]] | ||
| + | [[Category: Shiiyama Y]] | ||
| + | [[Category: Uchii K]] | ||
Revision as of 05:29, 9 August 2023
X-ray structure of human PPAR delta ligand binding domain-seladelpar co-crystals obtained by co-crystallization
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Categories: Homo sapiens | Large Structures | Honda A | Ishii I | Kamata S | Machida Y | Masuda R | Oyama T | Shiiyama Y | Uchii K
