8jpd

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Current revision (05:30, 9 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8jpd is ON HOLD until Paper Publication
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==Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes==
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<StructureSection load='8jpd' size='340' side='right'caption='[[8jpd]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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Authors: Duan, J., Liu, H., Zhao, F., Yuan, Q., Ji, Y., Xu, H.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JPD FirstGlance]. <br>
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Description: Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr>
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[[Category: Xu, H.E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jpd OCA], [https://pdbe.org/8jpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jpd RCSB], [https://www.ebi.ac.uk/pdbsum/8jpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jpd ProSAT]</span></td></tr>
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[[Category: Duan, J]]
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</table>
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[[Category: Zhao, F]]
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== Function ==
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[[Category: Liu, H]]
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[https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).
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[[Category: Yuan, Q]]
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__TOC__
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[[Category: Ji, Y]]
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Large Structures]]
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[[Category: Duan J]]
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[[Category: Ji Y]]
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[[Category: Liu H]]
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[[Category: Xu HE]]
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[[Category: Yuan Q]]
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[[Category: Zhao F]]

Current revision

Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes

PDB ID 8jpd

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OCA

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