8tfg

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m (Protected "8tfg" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8tfg is ON HOLD
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==1.88A CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TOPOISOMERASE I==
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<StructureSection load='8tfg' size='340' side='right'caption='[[8tfg]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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Authors: Tan, K., Tse-Dinh, Y.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tfg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TFG FirstGlance]. <br>
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Description: 1.88A CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TOPOISOMERASE I
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Tse-Dinh, Y.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tfg OCA], [https://pdbe.org/8tfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tfg RCSB], [https://www.ebi.ac.uk/pdbsum/8tfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tfg ProSAT]</span></td></tr>
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[[Category: Tan, K]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0E8VY41_MYCTX A0A0E8VY41_MYCTX] Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.[HAMAP-Rule:MF_00952]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Tan K]]
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[[Category: Tse-Dinh YC]]

Revision as of 05:33, 9 August 2023

1.88A CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TOPOISOMERASE I

PDB ID 8tfg

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