8tco
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab== | |
| - | + | <StructureSection load='8tco' size='340' side='right'caption='[[8tco]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8tco]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TCO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tco OCA], [https://pdbe.org/8tco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tco RCSB], [https://www.ebi.ac.uk/pdbsum/8tco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tco ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8JP80_HCMV Q8JP80_HCMV] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.[HAMAP-Rule:MF_04036] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human betaherpesvirus 5]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Goldsmith JG]] | ||
| + | [[Category: McLellan JS]] | ||
Revision as of 05:33, 9 August 2023
HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab
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