8tco

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8tco" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8tco is ON HOLD
+
==HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab==
-
 
+
<StructureSection load='8tco' size='340' side='right'caption='[[8tco]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8tco]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TCO FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tco OCA], [https://pdbe.org/8tco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tco RCSB], [https://www.ebi.ac.uk/pdbsum/8tco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tco ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8JP80_HCMV Q8JP80_HCMV] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.[HAMAP-Rule:MF_04036]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Human betaherpesvirus 5]]
 +
[[Category: Large Structures]]
 +
[[Category: Goldsmith JG]]
 +
[[Category: McLellan JS]]

Revision as of 05:33, 9 August 2023

HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab

PDB ID 8tco

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools