1ckn

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Current revision (05:53, 9 August 2023) (edit) (undo)
 
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<StructureSection load='1ckn' size='340' side='right'caption='[[1ckn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1ckn' size='340' side='right'caption='[[1ckn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ckn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorella_pbcv-1_virus Chlorella pbcv-1 virus]. The January 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ckn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. The January 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPL:LYSINE+GUANOSINE-5-MONOPHOSPHATE'>GPL</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GPL:LYSINE+GUANOSINE-5-MONOPHOSPHATE'>GPL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/mRNA_guanylyltransferase mRNA guanylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.50 2.7.7.50] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckn OCA], [https://pdbe.org/1ckn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckn RCSB], [https://www.ebi.ac.uk/pdbsum/1ckn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckn OCA], [https://pdbe.org/1ckn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckn RCSB], [https://www.ebi.ac.uk/pdbsum/1ckn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckn ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_PBCV1 MCE_PBCV1] mRNA capping. Transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chlorella pbcv-1 virus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Messenger RNA Capping]]
[[Category: Messenger RNA Capping]]
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[[Category: Paramecium bursaria Chlorella virus 1]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: MRNA guanylyltransferase]]
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[[Category: Doherty AJ]]
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[[Category: Doherty, A J]]
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[[Category: Hakansson K]]
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[[Category: Hakansson, K]]
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[[Category: Wigley DB]]
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[[Category: Wigley, D B]]
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[[Category: Capping enzyme]]
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[[Category: Mrna]]
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[[Category: Nucleotidyltransferase]]
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Current revision

STRUCTURE OF GUANYLYLATED MRNA CAPPING ENZYME COMPLEXED WITH GTP

PDB ID 1ckn

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