1i1r

From Proteopedia

(Difference between revisions)

Revision as of 06:19, 9 August 2023

CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX

Structural highlights

1i1r is a 2 chain structure with sequence from Homo sapiens and Human gammaherpesvirus 8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL6RB_HUMAN Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma-associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling assembly between viral IL-6 and human gp130, two complexes are cross-linked into a tetramer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-6, which is necessary for receptor activation. Unlike human IL-6 (which uses many hydrophilic residues), the viral cytokine largely uses hydrophobic amino acids to contact gp130, which enhances the complementarity of the viral IL-6-gp130 binding interfaces. The cross-reactivity of gp130 is apparently due to a chemical plasticity evident in the amphipathic gp130 cytokine-binding sites.

Structure of an extracellular gp130 cytokine receptor signaling complex.,Chow D, He X, Snow AL, Rose-John S, Garcia KC Science. 2001 Mar 16;291(5511):2150-5. PMID:11251120^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chow D, He X, Snow AL, Rose-John S, Garcia KC. Structure of an extracellular gp130 cytokine receptor signaling complex. Science. 2001 Mar 16;291(5511):2150-5. PMID:11251120 doi:10.1126/science.1058308

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i1r"

@@ Line 3: / Line 3: @@
 <StructureSection load='1i1r' size='340' side='right'caption='[[1i1r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1i1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-8 Hhv-8] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1i1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1R FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [https://pdbe.org/1i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB], [https://www.ebi.ac.uk/pdbsum/1i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1r ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [https://pdbe.org/1i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB], [https://www.ebi.ac.uk/pdbsum/1i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1r ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN]] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
+[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Hhv-8]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
+[[Category: Human gammaherpesvirus 8]]
 [[Category: Large Structures]]
-[[Category: Chow, D]]
+[[Category: Chow D]]
-[[Category: Garcia, K C]]
+[[Category: Garcia KC]]
-[[Category: He, X]]
+[[Category: He X]]
-[[Category: Rose-John, S]]
+[[Category: Rose-John S]]
-[[Category: Snow, A L]]
+[[Category: Snow AL]]
-[[Category: Cytokine]]
-[[Category: Cytokine-receptor complex]]
-[[Category: Gp130]]
-[[Category: Viral il-6]]

1i1r

From Proteopedia

Revision as of 06:19, 9 August 2023

CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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