1lwv

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[[Image:1lwv.gif|left|200px]]
[[Image:1lwv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lwv |SIZE=350|CAPTION= <scene name='initialview01'>1lwv</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1lwv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANG:8-AMINOGUANINE'>ANG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PED:PENTANE-3,4-DIOL-5-PHOSPHATE'>PED</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ogg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1lwv| PDB=1lwv | SCENE= }}
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|RELATEDENTRY=[[1ebm|1EBM]], [[1fn7|1FN7]], [[1hu0|1HU0]], [[1lww|1lww]], [[1lwy|1lwy]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lwv OCA], [http://www.ebi.ac.uk/pdbsum/1lwv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lwv RCSB]</span>
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}}
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'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine'''
'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine'''
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[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
[[Category: Yang, W.]]
[[Category: Yang, W.]]
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[[Category: borohydride]]
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[[Category: Borohydride]]
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[[Category: covalent trapping]]
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[[Category: Covalent trapping]]
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[[Category: dna glycosylase]]
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[[Category: Dna glycosylase]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: product-assisted catalysis]]
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[[Category: Product-assisted catalysis]]
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[[Category: protein/dna]]
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[[Category: Protein/dna]]
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[[Category: reaction intermediate]]
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[[Category: Reaction intermediate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:22:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:30 2008''
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Revision as of 21:22, 2 May 2008

Image:1lwv.gif

Template:STRUCTURE 1lwv

Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine


Overview

Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.

About this Structure

1LWV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Product-assisted catalysis in base-excision DNA repair., Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL, Nat Struct Biol. 2003 Mar;10(3):204-11. PMID:12592398 Page seeded by OCA on Sat May 3 00:22:52 2008

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OCA

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