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| | <StructureSection load='1osz' size='340' side='right'caption='[[1osz]], [[Resolution|resolution]] 2.10Å' scene=''> | | <StructureSection load='1osz' size='340' side='right'caption='[[1osz]], [[Resolution|resolution]] 2.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1osz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1OSZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1osz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSZ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H-2B BETA2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osz OCA], [http://pdbe.org/1osz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1osz RCSB], [http://www.ebi.ac.uk/pdbsum/1osz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1osz ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osz OCA], [https://pdbe.org/1osz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osz RCSB], [https://www.ebi.ac.uk/pdbsum/1osz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osz ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Chang, H C]] | + | [[Category: Chang H-C]] |
| - | [[Category: Ghendler, Y]] | + | [[Category: Ghendler Y]] |
| - | [[Category: Kern, P]] | + | [[Category: Kern P]] |
| - | [[Category: Kim, K S]] | + | [[Category: Kim KS]] |
| - | [[Category: Liu, J]] | + | [[Category: Liu J]] |
| - | [[Category: Liu, J H]] | + | [[Category: Liu J-H]] |
| - | [[Category: Reinherz, E L]] | + | [[Category: Reinherz EL]] |
| - | [[Category: Teng, M K]] | + | [[Category: Teng M-K]] |
| - | [[Category: Wang, J H]] | + | [[Category: Wang J-H]] |
| - | [[Category: Witte, T]] | + | [[Category: Witte T]] |
| - | [[Category: Mhc-peptide complex]]
| + | |
| - | [[Category: Thymic selection]]
| + | |
| - | [[Category: Transmembrane protein]]
| + | |
| Structural highlights
Function
HA1B_MOUSE Involved in the presentation of foreign antigens to the immune system.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide variant V4L (L4) inducing phenotypic and functional T cell maturation. The cognate VSV8 peptide, in contrast, triggers negative selection. The crystal structure of L4/Kb was determined and refined to 2.1 A for comparison with the VSV8/Kb structure at similar resolution. Aside from changes on the p4 side chain of L4 and the resulting alteration of the exposed Kb Lys-66 side chain, these two structures are essentially identical. Hence, a given TCR recognizes subtle distinctions between highly related ligands, resulting in dramatically different selection outcomes. Based on these finding and the recent structural elucidation of the N15-VSV8/Kb complex, moreover, it appears that the germ-line Valpha repertoire contributes in a significant way to positive selection.
Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.,Ghendler Y, Teng MK, Liu JH, Witte T, Liu J, Kim KS, Kern P, Chang HC, Wang JH, Reinherz EL Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10061-6. PMID:9707600[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ghendler Y, Teng MK, Liu JH, Witte T, Liu J, Kim KS, Kern P, Chang HC, Wang JH, Reinherz EL. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10061-6. PMID:9707600
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