1lx5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1lx5.gif|left|200px]]
[[Image:1lx5.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1lx5 |SIZE=350|CAPTION= <scene name='initialview01'>1lx5</scene>, resolution 3.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1lx5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BMP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ACVR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1lx5| PDB=1lx5 | SCENE= }}
-
|RELATEDENTRY=[[1lxi|1LXI]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lx5 OCA], [http://www.ebi.ac.uk/pdbsum/1lx5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lx5 RCSB]</span>
+
-
}}
+
'''Crystal Structure of the BMP7/ActRII Extracellular Domain Complex'''
'''Crystal Structure of the BMP7/ActRII Extracellular Domain Complex'''
Line 30: Line 27:
[[Category: Groppe, J.]]
[[Category: Groppe, J.]]
[[Category: Kwiatkowski, W.]]
[[Category: Kwiatkowski, W.]]
-
[[Category: ligand-receptor complex]]
+
[[Category: Ligand-receptor complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:10 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:31 2008''
+

Revision as of 21:23, 2 May 2008

Image:1lx5.gif

Template:STRUCTURE 1lx5

Crystal Structure of the BMP7/ActRII Extracellular Domain Complex


Overview

Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related type I and type II receptors. Here we report the crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor. Our structure produces a compelling four-receptor model, revealing that the types I and II receptor ECDs make no direct contacts. Nevertheless, we find that truncated receptors lacking their cytoplasmic domain retain the ability to cooperatively assemble in the cell membrane. Also, the affinity of BMP7 for its low-affinity type I receptor ECD increases 5-fold in the presence of its type II receptor ECD. Taken together, our results provide a view of the ligand-mediated cooperative assembly of BMP and activin receptors that does not rely on receptor-receptor contacts.

About this Structure

1LX5 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly., Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S, Mol Cell. 2003 Mar;11(3):605-17. PMID:12667445 Page seeded by OCA on Sat May 3 00:23:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lx5"
Personal tools