1lx7

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[[Image:1lx7.gif|left|200px]]
[[Image:1lx7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1lx7 |SIZE=350|CAPTION= <scene name='initialview01'>1lx7</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1lx7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK11178 PRK11178]</span>
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{{STRUCTURE_1lx7| PDB=1lx7 | SCENE= }}
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|RELATEDENTRY=[[1k3f|1k3f]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lx7 OCA], [http://www.ebi.ac.uk/pdbsum/1lx7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lx7 RCSB]</span>
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}}
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'''Structure of E. coli uridine phosphorylase at 2.0A'''
'''Structure of E. coli uridine phosphorylase at 2.0A'''
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[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nucleotide metabolism]]
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[[Category: Nucleotide metabolism]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: p12758]]
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[[Category: P12758]]
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[[Category: phosphorylase]]
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[[Category: Phosphorylase]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: udrpase]]
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[[Category: Udrpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:31 2008''
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Revision as of 21:23, 2 May 2008

Image:1lx7.gif

Template:STRUCTURE 1lx7

Structure of E. coli uridine phosphorylase at 2.0A


Overview

The 2.0 A crystal structure has been determined for Escherichia coli uridine phosphorylase (UP), an essential enzyme in nucleotide biosynthesis that catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose-1-phosphate and uracil. The structure determination of two independent monomers in the asymmetric unit revealed the residue composition and atomic details of the apo configurations of each active site. The native hexameric UP enzyme was revealed by applying threefold crystallographic symmetry to the contents of the asymmetric unit. The 2.0 A model reveals a closer structural relationship to other nucleotide phosphorylase enzymes than was previously appreciated.

About this Structure

1LX7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli uridine phosphorylase at 2.0 A., Burling FT, Kniewel R, Buglino JA, Chadha T, Beckwith A, Lima CD, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):73-6. Epub 2002 Dec, 19. PMID:12499542 Page seeded by OCA on Sat May 3 00:23:21 2008

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