1lxa

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[[Image:1lxa.jpg|left|200px]]
[[Image:1lxa.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lxa |SIZE=350|CAPTION= <scene name='initialview01'>1lxa</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1lxa", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine_O-acyltransferase Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.129 2.3.1.129] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= LPXA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1lxa| PDB=1lxa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lxa OCA], [http://www.ebi.ac.uk/pdbsum/1lxa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lxa RCSB]</span>
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}}
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'''UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE'''
'''UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE'''
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==Reference==
==Reference==
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase., Raetz CR, Roderick SL, Science. 1995 Nov 10;270(5238):997-1000. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7481807 7481807]
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase., Raetz CR, Roderick SL, Science. 1995 Nov 10;270(5238):997-1000. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7481807 7481807]
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[[Category: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Roderick, S L.]]
[[Category: Roderick, S L.]]
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[[Category: acyltransferase]]
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[[Category: Acyltransferase]]
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[[Category: lipid a biosynthesis]]
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[[Category: Lipid a biosynthesis]]
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[[Category: lipid synthesis]]
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[[Category: Lipid synthesis]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:30 2008''
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Revision as of 21:23, 2 May 2008

Image:1lxa.jpg

Template:STRUCTURE 1lxa

UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE


Overview

UDP-N-acetylglucosamine 3-O-acyltransferase (LpxA) catalyzes the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-N-acetylglucosamine. LpxA is the first enzyme in the lipid A biosynthetic pathway and is a target for the design of antibiotics. The x-ray crystal structure of LpxA has been determined to 2.6 angstrom resolution and reveals a domain motif composed of parallel beta strands, termed a left-handed parallel beta helix (L beta H). This unusual fold displays repeated violations of the protein folding constraint requiring right-handed crossover connections between strands of parallel beta sheets and may be present in other enzymes that share amino acid sequence homology to the repeated hexapeptide motif of LpxA.

About this Structure

1LXA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase., Raetz CR, Roderick SL, Science. 1995 Nov 10;270(5238):997-1000. PMID:7481807 Page seeded by OCA on Sat May 3 00:23:25 2008

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