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2fiv

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Current revision (06:44, 9 August 2023) (edit) (undo)
 
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<StructureSection load='2fiv' size='340' side='right'caption='[[2fiv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2fiv' size='340' side='right'caption='[[2fiv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2fiv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Fiv Fiv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FIV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2fiv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus Feline immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FIV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALN:NAPHTHALEN-2-YL-3-ALANINE'>ALN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALN:NAPHTHALEN-2-YL-3-ALANINE'>ALN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fiv OCA], [https://pdbe.org/2fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fiv RCSB], [https://www.ebi.ac.uk/pdbsum/2fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fiv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fiv OCA], [https://pdbe.org/2fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fiv RCSB], [https://www.ebi.ac.uk/pdbsum/2fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fiv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE]] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
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[https://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fiv]]
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[[Category: Feline immunodeficiency virus]]
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[[Category: HIV-1 retropepsin]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gustchina, A]]
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[[Category: Gustchina A]]
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[[Category: Lubkowski, J]]
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[[Category: Lubkowski J]]
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[[Category: Schalk-Hihi, C]]
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[[Category: Schalk-Hihi C]]
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[[Category: Wlodawer, A]]
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[[Category: Wlodawer A]]
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[[Category: Zdanov, A]]
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[[Category: Zdanov A]]
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[[Category: Acid proteinase-substrate]]
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[[Category: Aspartic protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Retroviral protease]]
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Current revision

Crystal structure of feline immunodeficiency virus protease complexed with a substrate

PDB ID 2fiv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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