This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1luj
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1luj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1luj, resolution 2.50Å" /> '''Crystal Structure o...)
Next diff →
Revision as of 15:57, 12 November 2007
|
Crystal Structure of the Beta-catenin/ICAT Complex
Contents |
Overview
Beta-catenin is a multifunctional protein involved in both cell adhesion, and transcriptional activation. Transcription mediated by the, beta-catenin/Tcf complex is involved in embryological development and is, upregulated in various cancers. We have determined the crystal structure, at 2.5 A resolution of a complex between beta-catenin and ICAT, a protein, that prevents the interaction between beta-catenin and Tcf/Lef family, transcription factors. ICAT contains a 3-helix bundle that binds armadillo, repeats 10-12 and a C-terminal tail that, similar to Tcf and E-cadherin, binds in the groove formed by armadillo repeats 5-9 of beta-catenin. We, show that ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions. Thus, it should be, possible to design cancer therapeutics that inhibit beta-catenin-mediated, transcriptional activation without interfering with cell adhesion.
Disease
Known diseases associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]
About this Structure
1LUJ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT., Graham TA, Clements WK, Kimelman D, Xu W, Mol Cell. 2002 Sep;10(3):563-71. PMID:12408824
Page seeded by OCA on Mon Nov 12 18:04:16 2007
