5h46

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Current revision (07:23, 9 August 2023) (edit) (undo)
 
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==Mycobacterium smegmatis Dps1 mutant - F47E==
==Mycobacterium smegmatis Dps1 mutant - F47E==
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<StructureSection load='5h46' size='340' side='right' caption='[[5h46]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='5h46' size='340' side='right'caption='[[5h46]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h46]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H46 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H46 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dps, MSMEG_6467, MSMEI_6295 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h46 OCA], [http://pdbe.org/5h46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h46 RCSB], [http://www.ebi.ac.uk/pdbsum/5h46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h46 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h46 OCA], [https://pdbe.org/5h46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h46 RCSB], [https://www.ebi.ac.uk/pdbsum/5h46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h46 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPS_MYCS2 DPS_MYCS2]] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage (By similarity).
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[https://www.uniprot.org/uniprot/DPS_MYCS2 DPS_MYCS2] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycs2]]
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[[Category: Large Structures]]
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[[Category: Chandran, A V]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Chatterji, D]]
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[[Category: Chandran AV]]
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[[Category: Vijayan, M]]
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[[Category: Chatterji D]]
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[[Category: Williams, S M]]
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[[Category: Vijayan M]]
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[[Category: Mutational tipping point]]
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[[Category: Williams SM]]
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[[Category: Oligomerisation]]
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[[Category: Oxidoreductase]]
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[[Category: Point mutant]]
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[[Category: Structural switch]]
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Current revision

Mycobacterium smegmatis Dps1 mutant - F47E

PDB ID 5h46

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