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5h7r

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Current revision (07:26, 9 August 2023) (edit) (undo)
 
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==Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain==
==Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain==
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<StructureSection load='5h7r' size='340' side='right' caption='[[5h7r]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='5h7r' size='340' side='right'caption='[[5h7r]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H7R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H7R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h7s|5h7s]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LNX1, LNX, PDZRN2, UNQ574/PRO1136 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7r OCA], [https://pdbe.org/5h7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h7r RCSB], [https://www.ebi.ac.uk/pdbsum/5h7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7r OCA], [http://pdbe.org/5h7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h7r RCSB], [http://www.ebi.ac.uk/pdbsum/5h7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LNX1_HUMAN LNX1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). Isoform 2 provides an endocytic scaffold for IGSF5/JAM4 (By similarity).
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[https://www.uniprot.org/uniprot/LNX1_HUMAN LNX1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). Isoform 2 provides an endocytic scaffold for IGSF5/JAM4 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h7r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h7r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Nayak, D]]
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[[Category: Large Structures]]
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[[Category: Sivaraman, J]]
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[[Category: Nayak D]]
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[[Category: E3 ligase]]
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[[Category: Sivaraman J]]
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[[Category: Ligase]]
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[[Category: Ring]]
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[[Category: Ubiquitination]]
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[[Category: Zn finger motif]]
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Current revision

Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain

PDB ID 5h7r

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