From Proteopedia
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- | | + | #REDIRECT [[8pc6]] This PDB entry is obsolete and replaced by 8pc6 |
- | ==H3K36 tri-methylated nucleosome LEDGF PWWP domain complex pose 2==
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- | <StructureSection load='7pgw' size='340' side='right'caption='[[7pgw]], [[Resolution|resolution]] 7.00Å' scene=''>
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- | == Structural highlights ==
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- | <table><tr><td colspan='2'>[[7pgw]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGW FirstGlance]. <br>
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- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr>
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- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgw OCA], [https://pdbe.org/7pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgw RCSB], [https://www.ebi.ac.uk/pdbsum/7pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgw ProSAT]</span></td></tr>
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- | </table>
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- | == Function ==
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- | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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- | __TOC__
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- | </StructureSection>
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- | [[Category: Homo sapiens]]
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- | [[Category: Large Structures]]
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- | [[Category: Synthetic construct]]
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- | [[Category: Xenopus laevis]]
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- | [[Category: Hexnerova R]]
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- | [[Category: Koutna E]]
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- | [[Category: Lux V]]
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- | [[Category: Novacek J]]
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- | [[Category: Poepsel S]]
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- | [[Category: Skerlova J]]
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- | [[Category: Srb P]]
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- | [[Category: Veverka V]]
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Current revision
- REDIRECT 8pc6 This PDB entry is obsolete and replaced by 8pc6