7yrn
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab== | |
| - | + | <StructureSection load='7yrn' size='340' side='right'caption='[[7yrn]], [[Resolution|resolution]] 2.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yrn]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YRN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yrn OCA], [https://pdbe.org/7yrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yrn RCSB], [https://www.ebi.ac.uk/pdbsum/7yrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yrn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B9VXM4_HCMVT B9VXM4_HCMVT] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.[HAMAP-Rule:MF_04032] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human betaherpesvirus 5]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liao H]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Zhu S]] | ||
Revision as of 08:16, 16 August 2023
Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab
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