8af2

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Current revision (08:17, 16 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8af2 is ON HOLD until Paper Publication
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==Human Sterol Carrier Protein with unnatural amino acid 2,2'-bipyridine alanine incorporated at position 111==
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<StructureSection load='8af2' size='340' side='right'caption='[[8af2]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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Authors: Richardson, J.M., Klemencic, E., Jarvis, A.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8af2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AF2 FirstGlance]. <br>
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Description: Human Sterol Carrier Protein with unnatural amino acid 2,2''-bipyridine alanine incorporated at position 111
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRT:FRAGMENT+OF+TRITON+X-100'>TRT</scene></td></tr>
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[[Category: Jarvis, A.G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8af2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8af2 OCA], [https://pdbe.org/8af2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8af2 RCSB], [https://www.ebi.ac.uk/pdbsum/8af2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8af2 ProSAT]</span></td></tr>
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[[Category: Richardson, J.M]]
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</table>
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[[Category: Klemencic, E]]
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== Disease ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jarvis AG]]
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[[Category: Klemencic E]]
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[[Category: Richardson JM]]

Current revision

Human Sterol Carrier Protein with unnatural amino acid 2,2'-bipyridine alanine incorporated at position 111

PDB ID 8af2

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