8p5r

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Current revision (08:29, 16 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8p5r is ON HOLD until Paper Publication
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==Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA==
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<StructureSection load='8p5r' size='340' side='right'caption='[[8p5r]], [[Resolution|resolution]] 4.56&Aring;' scene=''>
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Authors: Wagner, T., Mechaly, A.M., Alzari, P.M., Bellinzoni, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p5r]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P5R FirstGlance]. <br>
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Description: Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.562&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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[[Category: Bellinzoni, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p5r OCA], [https://pdbe.org/8p5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p5r RCSB], [https://www.ebi.ac.uk/pdbsum/8p5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p5r ProSAT]</span></td></tr>
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[[Category: Wagner, T]]
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</table>
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[[Category: Alzari, P.M]]
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== Function ==
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[[Category: Mechaly, A.M]]
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[https://www.uniprot.org/uniprot/KGD_MYCS2 KGD_MYCS2] Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle.<ref>PMID:19019160</ref> <ref>PMID:21867916</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Alzari PM]]
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[[Category: Bellinzoni M]]
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[[Category: Mechaly AM]]
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[[Category: Wagner T]]

Current revision

Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA

PDB ID 8p5r

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