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1jhe

From Proteopedia

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Current revision (08:40, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1jhe' size='340' side='right'caption='[[1jhe]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1jhe' size='340' side='right'caption='[[1jhe]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1jhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1jhe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jhc|1jhc]], [[1jhf|1jhf]], [[1jhh|1jhh]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LexA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Repressor_lexA Repressor lexA], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.88 3.4.21.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhe OCA], [https://pdbe.org/1jhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhe RCSB], [https://www.ebi.ac.uk/pdbsum/1jhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhe OCA], [https://pdbe.org/1jhe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhe RCSB], [https://www.ebi.ac.uk/pdbsum/1jhe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
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[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Repressor lexA]]
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[[Category: J Strynadka NC]]
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[[Category: Little, J W]]
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[[Category: Little JW]]
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[[Category: Luo, Y]]
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[[Category: Luo Y]]
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[[Category: Mosimann, S]]
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[[Category: Mosimann S]]
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[[Category: Pfuetzner, R A]]
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[[Category: Pfuetzner RA]]
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[[Category: Strynadka, N C.J]]
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[[Category: C-terminal]]
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[[Category: Hydrolase]]
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[[Category: Lexa sos repressor]]
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Current revision

LEXA L89P Q92W E152A K156A MUTANT

PDB ID 1jhe

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