1m0t

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[[Image:1m0t.jpg|left|200px]]
[[Image:1m0t.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1m0t |SIZE=350|CAPTION= <scene name='initialview01'>1m0t</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1m0t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= GSH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00228 eu-GS]</span>
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{{STRUCTURE_1m0t| PDB=1m0t | SCENE= }}
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|RELATEDENTRY=[[2hgs|2HGS]], [[1m0w|1M0W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m0t OCA], [http://www.ebi.ac.uk/pdbsum/1m0t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m0t RCSB]</span>
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}}
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'''Yeast Glutathione Synthase'''
'''Yeast Glutathione Synthase'''
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
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[[Category: amine/carboxylate ligase]]
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[[Category: Amine/carboxylate ligase]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:29:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:09:46 2008''
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Revision as of 21:29, 2 May 2008

Image:1m0t.jpg

Template:STRUCTURE 1m0t

Yeast Glutathione Synthase


Overview

Glutathione synthase catalyzes the final ATP-dependent step in glutathione biosynthesis, the formation of glutathione from gamma-glutamylcysteine and glycine. We have determined structures of yeast glutathione synthase in two forms: unbound (2.3 A resolution) and bound to its substrate gamma-glutamylcysteine, the ATP analog AMP-PNP, and two magnesium ions (1.8 A resolution). These structures reveal that upon substrate binding, large domain motions convert the enzyme from an open unliganded form to a closed conformation in which protein domains completely surround the substrate in the active site.

About this Structure

1M0T is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Large conformational changes in the catalytic cycle of glutathione synthase., Gogos A, Shapiro L, Structure. 2002 Dec;10(12):1669-76. PMID:12467574 Page seeded by OCA on Sat May 3 00:29:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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