1jtx

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Current revision (08:46, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1jtx' size='340' side='right'caption='[[1jtx]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='1jtx' size='340' side='right'caption='[[1jtx]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1jtx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1jtx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVI:CRYSTAL+VIOLET'>CVI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jty|1jty]], [[1jum|1jum]], [[1jup|1jup]], [[1jus|1jus]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVI:CRYSTAL+VIOLET'>CVI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtx OCA], [https://pdbe.org/1jtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jtx RCSB], [https://www.ebi.ac.uk/pdbsum/1jtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jtx OCA], [https://pdbe.org/1jtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jtx RCSB], [https://www.ebi.ac.uk/pdbsum/1jtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jtx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
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[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brennan, R G]]
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[[Category: Staphylococcus aureus]]
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[[Category: Brown, M H]]
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[[Category: Brennan RG]]
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[[Category: Grkovic, S]]
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[[Category: Brown MH]]
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[[Category: Miller, M C]]
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[[Category: Grkovic S]]
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[[Category: Schumacher, M A]]
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[[Category: Miller MC]]
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[[Category: Skurray, R A]]
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[[Category: Schumacher MA]]
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[[Category: Multidrug binding]]
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[[Category: Skurray RA]]
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[[Category: Multidrug recognition]]
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[[Category: Qaca]]
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[[Category: Qacr]]
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[[Category: Repressor]]
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[[Category: S. aureus]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the multidrug binding transcriptional regulator QacR bound to crystal violet

PDB ID 1jtx

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