1m1a

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[[Image:1m1a.gif|left|200px]]
[[Image:1m1a.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1m1a |SIZE=350|CAPTION= <scene name='initialview01'>1m1a</scene>, resolution 2.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1m1a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DIB:3-AMINO-(DIMETHYLPROPYLAMINE)'>DIB</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=IMT:4-AMINO-(1-METHYLIMIDAZOLE)-2-CARBOXYLIC+ACID'>IMT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYB:4-AMINO-(1-METHYLPYRROLE)-2-CARBOXYLIC+ACID'>PYB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1m1a| PDB=1m1a | SCENE= }}
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|RELATEDENTRY=[[1aoi|1AOI]], [[1m18|1M18]], [[1m19|1M19]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1a OCA], [http://www.ebi.ac.uk/pdbsum/1m1a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m1a RCSB]</span>
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}}
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'''LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA'''
'''LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA'''
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[[Category: Suto, R K.]]
[[Category: Suto, R K.]]
[[Category: White, C L.]]
[[Category: White, C L.]]
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[[Category: chromatin]]
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[[Category: Chromatin]]
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[[Category: chromatin remodeling]]
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[[Category: Chromatin remodeling]]
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[[Category: dna regognition]]
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[[Category: Dna regognition]]
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[[Category: histone]]
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[[Category: Histone]]
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[[Category: nucleosome]]
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[[Category: Nucleosome]]
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[[Category: pyrrole-imidazole polyamide]]
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[[Category: Pyrrole-imidazole polyamide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:30:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:09:57 2008''
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Revision as of 21:30, 2 May 2008

Image:1m1a.gif

Template:STRUCTURE 1m1a

LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA


Overview

We determined the crystal structures of three nucleosome core particles in complex with site-specific DNA-binding ligands, the pyrrole-imidazole polyamides. While the structure of the histone octamer and its interaction with the DNA remain unaffected by ligand binding, nucleosomal DNA undergoes significant structural changes at the ligand-binding sites and in adjacent regions to accommodate the ligands. Our findings suggest that twist diffusion occurs over long distances through tightly bound nucleosomal DNA. This may be relevant to the mechanism of ATP-dependent and spontaneous nucleosome translocation, and to the effect of bound factors on nucleosome dynamics.

About this Structure

1M1A is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands., Suto RK, Edayathumangalam RS, White CL, Melander C, Gottesfeld JM, Dervan PB, Luger K, J Mol Biol. 2003 Feb 14;326(2):371-80. PMID:12559907 Page seeded by OCA on Sat May 3 00:30:40 2008

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