1m1f

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[[Image:1m1f.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_1m1f| PDB=1m1f | SCENE= }}
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|RELATEDENTRY=[[4vub|4VUB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1f OCA], [http://www.ebi.ac.uk/pdbsum/1m1f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m1f RCSB]</span>
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'''Kid toxin protein from E.coli plasmid R1'''
'''Kid toxin protein from E.coli plasmid R1'''
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[[Category: Sabariegos-Jareno, R.]]
[[Category: Sabariegos-Jareno, R.]]
[[Category: Santos-Sierra, S.]]
[[Category: Santos-Sierra, S.]]
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[[Category: ccdb]]
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[[Category: Ccdb]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: mutational analysis]]
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[[Category: Mutational analysis]]
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[[Category: plasmid maintenance]]
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[[Category: Plasmid maintenance]]
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[[Category: post segregational killing]]
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[[Category: Post segregational killing]]
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[[Category: toxin-antitoxin]]
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[[Category: Toxin-antitoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:02 2008''
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Revision as of 21:31, 2 May 2008

Image:1m1f.jpg

Template:STRUCTURE 1m1f

Kid toxin protein from E.coli plasmid R1


Overview

We have determined the structure of Kid toxin protein from E. coli plasmid R1 involved in stable plasmid inheritance by postsegregational killing of plasmid-less daughter cells. Kid forms a two-component system with its antagonist, Kis antitoxin. Our 1.4 A crystal structure of Kid reveals a 2-fold symmetric dimer that closely resembles the DNA gyrase-inhibitory toxin protein CcdB from E. coli F plasmid despite the lack of any notable sequence similarity. Analysis of nontoxic mutants of Kid suggests a target interaction interface associated with toxicity that is in marked contrast to that proposed for CcdB. A possible region for interaction of Kid with the antitoxin is proposed that overlaps with the target binding site and may explain the mode of antitoxin action.

About this Structure

1M1F is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and functional analysis of the kid toxin protein from E. coli plasmid R1., Hargreaves D, Santos-Sierra S, Giraldo R, Sabariegos-Jareno R, de la Cueva-Mendez G, Boelens R, Diaz-Orejas R, Rafferty JB, Structure. 2002 Oct;10(10):1425-33. PMID:12377128 Page seeded by OCA on Sat May 3 00:31:01 2008

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