1km8
From Proteopedia
(Difference between revisions)
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<StructureSection load='1km8' size='340' side='right'caption='[[1km8]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1km8' size='340' side='right'caption='[[1km8]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1km8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1km8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KM8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1km8 OCA], [https://pdbe.org/1km8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1km8 RCSB], [https://www.ebi.ac.uk/pdbsum/1km8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1km8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1km8 OCA], [https://pdbe.org/1km8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1km8 RCSB], [https://www.ebi.ac.uk/pdbsum/1km8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1km8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RNASO_LITCT RNASO_LITCT] Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine. Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former. The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo. This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin. It is cytotoxic against several tumor cells. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Lithobates catesbeianus]] |
| - | + | [[Category: Amiraslanov IR]] | |
| - | [[Category: Amiraslanov | + | [[Category: Chern S-S]] |
| - | [[Category: Chern | + | [[Category: Liao Y-D]] |
| - | [[Category: Liao | + | [[Category: Liaw Y-C]] |
| - | [[Category: Liaw | + | [[Category: Musayev FN]] |
| - | [[Category: Musayev | + | |
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Revision as of 09:00, 16 August 2023
The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)
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