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1m24
From Proteopedia
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[[Image:1m24.jpg|left|200px]] | [[Image:1m24.jpg|left|200px]] | ||
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'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide''' | '''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M24 OCA]. | |
==Reference== | ==Reference== | ||
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12390019 12390019] | Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12390019 12390019] | ||
| - | [[Category: Protein complex]] | ||
| - | [[Category: Trichoderma viride]] | ||
[[Category: Brueckner, H.]] | [[Category: Brueckner, H.]] | ||
[[Category: Chugh, J K.]] | [[Category: Chugh, J K.]] | ||
[[Category: Wallace, B A.]] | [[Category: Wallace, B A.]] | ||
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Helical bundle]] |
| - | [[Category: | + | [[Category: Ion channel]] |
| - | [[Category: | + | [[Category: Peptaibol]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:32:40 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:32, 2 May 2008
Trichotoxin_A50E, An Ion Channel-Forming Polypeptide
Overview
Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
About this Structure
Full crystallographic information is available from OCA.
Reference
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:12390019 Page seeded by OCA on Sat May 3 00:32:40 2008
