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1nq3

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Crystal structure of the mammalian tumor associated antigen UK114

Structural highlights

1nq3 is a 6 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIDA_CAPHI Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.[UniProtKB:P52758] Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.[UniProtKB:P52758]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed.

Structure and oligomeric state of the mammalian tumour-associated antigen UK114.,Deriu D, Briand C, Mistiniene E, Naktinis V, Grutter MG Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1676-8. Epub 2003, Aug 19. PMID:12925811^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Deriu D, Briand C, Mistiniene E, Naktinis V, Grutter MG. Structure and oligomeric state of the mammalian tumour-associated antigen UK114. Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1676-8. Epub 2003, Aug 19. PMID:12925811

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nq3"

@@ Line 3: / Line 3: @@
 <StructureSection load='1nq3' size='340' side='right'caption='[[1nq3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/African_dwarf_goat African dwarf goat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQ3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQ3 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qd9|1qd9]], [[1qu9|1qu9]], [[1jd1|1jd1]], [[1j7h|1j7h]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nq3 OCA], [https://pdbe.org/1nq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nq3 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/UK114_CAPHI UK114_CAPHI]] Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).
+[https://www.uniprot.org/uniprot/RIDA_CAPHI RIDA_CAPHI] Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.[UniProtKB:P52758]  Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.[UniProtKB:P52758]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: African dwarf goat]]
+[[Category: Capra hircus]]
 [[Category: Large Structures]]
-[[Category: Briand, C]]
+[[Category: Briand C]]
-[[Category: Deriu, D]]
+[[Category: Deriu D]]
-[[Category: Grutter, M G]]
+[[Category: Grutter MG]]
-[[Category: Mistiniene, E]]
+[[Category: Mistiniene E]]
-[[Category: Naktinis, V]]
+[[Category: Naktinis V]]
-[[Category: Immune system]]
-[[Category: Metal binding protein]]
-[[Category: Trimer]]
-[[Category: Tumor associated antigen]]
-[[Category: Uk114]]
-[[Category: Yer057c/yil051c/yjgf protein family]]

1nq3

From Proteopedia

Current revision

Crystal structure of the mammalian tumor associated antigen UK114

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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