1pm1
From Proteopedia
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<StructureSection load='1pm1' size='340' side='right'caption='[[1pm1]], [[Resolution|resolution]] 1.10Å' scene=''> | <StructureSection load='1pm1' size='340' side='right'caption='[[1pm1]], [[Resolution|resolution]] 1.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1pm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1pm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PM1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm1 OCA], [https://pdbe.org/1pm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm1 OCA], [https://pdbe.org/1pm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NP2_RHOPR NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity). Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rhodnius prolixus]] |
| - | [[Category: Montfort | + | [[Category: Montfort WR]] |
| - | [[Category: Weichsel | + | [[Category: Weichsel A]] |
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Revision as of 09:45, 16 August 2023
Crystal structure of nitrophorin 2 L122V/L132V mutant complex with imidazole
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